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Fetal testing may be appropriate, based on the week of pregnancy. voriconazole and, in particular, fluconazole readily penetrated the blood-CSF/blood-brain barrier ( 222).
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Broth, agar, microdilution or equivalent methods may be used to determine the minimal inhibitory concentration (MIC) value for susceptibility of bacterial isolates using standardized methods, inoculums and concentrations of ampicillin/sulbactam. A reduction in metronidazole dosage by 50% is recommended in patients with severe (Child-Pugh C) hepatic impairment (see DOSAGE AND ADMINISTRATION).
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